The aim of the Neurobiology Group is to study the effects of environmental hazards on brain disorders. Brain disorders encompass neurological (i.e.: Alzheimer's disease, sleep disorders, chronic pain, epilepsy, glioblastoma) and neuropsychiatric (i.e.: Depression, anxiety, affective disorders) conditions and diseases. Most of them are multifactorial with interplay between environmental and genetic factors.
The goal of our group is to investigate the effects of environmental hazards on the epigenetics and cellular mechanisms underlying brain disorders and diseases using various methods such as cell culture, biochemistry and immunofluorescence, epigenetic editing with CRISPR-dCas9, epigenomics and proteomics, in vitro electrophysiology, and rodent animal models and behaviors.
Our current projects focus on neurodegenerative diseases and glioblastoma, and we are investigating:
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After obtaining a Master's degree in cellular and integrative neuroscience at University of Strasbourg (France) and a PhD in medicine in the field of neurophysiology of pain at University of Helsinki (Finland), Nora moved to the UK as a post-doc in neurobehavioural genetics at the MRC Harwell (UK) and then joined PHE to lead the Neurobiology group.
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We are continuously seeking potential collaborations with all research establishments (universities, institutes and government organisations) to study the effects of environmental agents on brain functions, epigenetics, and behaviour.
Contact us if you would like to find out more detail or stay informed about a particular field of research. We are always interested in collaborating and are open to partnerships, to drive forward innovation for the benefit of the public.